Indiana University School of Medicine, Ph.D., 2003
Department of Microbiology and Immunology
Doctoral Candidate, 1999
Indiana University-Purdue University, M.S.
Indiana University, B.S. Biochemistry
Research Interests
1. Investigate aspects of oral tolerance
a. The effect of antibiotic treatment on intestinal probiotic populations and the induction of oral tolerance
b. The effect of esophageal inflammation on oral tolerance induction
2. Investigate the ability of herbal supplements to alter specific immune functions
Recent Publications
Stankiewicz TE; Haaning KL; Owens JM; Jordan AS; Gammon K; Bruns HA; McDowell SA. GTPase activating protein function of p85 facilitates uptake and recycling of the ß1 integrin. (2009) Biochemical and Biophysical Research Communications. 391(1):443-448
Crane ED, Stephenson N, Haffner C, Bruns HA. Active Immune Response Protects Stat6VT Transgenic Mice from Developing a Lymphoproliferative Disorder. (2009) Immunobiology. 215(7):579-585
Thieu VT, Nguyen ET, McCarthy BP, Bruns HA, Kapur R, Chang CH and Kaplan MH. IL-4 stimulated NF-kappaB activity is required for Stat6 DNA binding. (2007) J Leuk Biol. 82: pp. – ePub ahead of print
Bruns HA, Kaplan MH. The Role of Constitutively Active Stat6 Proteins in Leukemia and Lymphoma. (2006) Critical Reviews in Oncology/Hematology 57: 245-253.
Chang H-C, Zhang S, Thieu VT, Slee RB, Bruns HA, Laribee RN, Klemsz MJ, Kaplan MH. PU.1 expression delineates heterogeneity in primary Th2 cells. (2005) Immunity, 22: 693-703
Bruns HA, Schindler U, Kaplan MH. Expression of a Constitutively Active Stat6 in vivo Alters Lymphocyte Homeostasis with Distinct Effects in T and B Cells. (2003) Journal of Immunology, 170: 3478-3487.
Broxmeyer HE, Bruns HA, Zhang S, Cooper S, Hangoc G, McKenzie AN, Dent AL, Schindler U, Naeger LK, Hoey T, and Kaplan MH. Th1 Cells Regulate Hematopoietic Progenitor Cell Homeostasis by Production of Oncostatin M. (2002) Immunity, 16: 815-825
Lawless VA, Zhang S, Ozes ON, Bruns HA, Oldham IL, Hoey T, Grusby MJ and Kaplan MH. Stat4 Regulates Multiple Components of IFN-gamma-inducing Signaling Pathways. (2000) Journal of Immunology, 165: 6803-6808