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CL 171d Phone: 765-285-8849
Department of Biology
Ball State University
Cooper Life Science Building, CL 121
Muncie, IN 47306
Indiana University School of Medicine, Ph.D., 2003
Department of Microbiology and Immunology
Doctoral Candidate, 1999
Indiana University-Purdue University, M.S.
Indiana University, B.S. Biochemistry
Research and Interest Areas
Over the past
11 years, I have established a diverse immunology research program. My lab has investigated the effects of broad
spectrum antibiotics and mucosal integrity on oral tolerance, and in
collaboration with my colleague, Susan McDowell, we have examined the
effects of simvastatin on immune responses following primary and secondary
infections with Staphyloccocus aureus.
my lab is exploring aspects of herbal medicinal therapy and investigating
specific immunologic mechanisms that can support or refute the effectiveness of
these treatments. Presently, we are
investigating the effect of extract from L.
japonica on B and T lymphocyte functions. L. japonica is an herb
commonly used in Chinese medicine and is known to have anti-inflammatory,
anti-bacterial, and anti-viral effects. While many investigations involving L.
japonica have examined its effects on innate immune responses, such as
inflammation, little is known is about how it may alter adaptive immune
responses involving B and T cells. While
my lab is currently investigating the effects of the extract of L. japonica on adaptive immune
functions, I have plans to expand our research to include additional herbs.
DeWalt, R. I., Petkovich, D. A., Zahrt, A. N., Bruns, H. A., McDowell, S. A. (2013).
Host cell invasion by Staphylococcus
aureus stimulates the shedding of microvesicles. BBRC, 432(4),
Erin M. Burns*,
Lisa K. Smelser*, Jenny E. Glassburn*, Traci E. Stankiewicz*, Michael
Kushdilian*, Susan A. McDowell, Heather
A. Bruns. Short term statin
treatment improves survival and differentially regulates macrophage-mediated
responses to Staphylococcus aureus.(2012)
Current Pharmaceutical Biotechnology. 2013 Feb;14(2):233-41.
Lambert*, Jeremy M. Kinder*, Jenny E. Then*, Kelly N. Parliament*, Heather A. Bruns. Erythromycin treatment hinders the induction of oral
tolerance to fed ovalbumin. (2012) Frontiers in Mucosal Immunity. 3:203.
Epub 2012 Jul 18.
L. Glosson, Heather A. Bruns, Mark
H. Kaplan. Wheezing and Itching: The
Requirement for STAT proteins in Allergic Inflammation. (2011) JAK-STAT. 1(1):3-12.
Stankiewicz TE; Haaning KL; Owens JM; Jordan AS; Gammon K; Bruns HA; McDowell SA. GTPase activating protein function of p85 facilitates uptake and recycling of the ß1 integrin. (2009) Biochemical and Biophysical Research Communications. 391(1):443-448
Crane ED, Stephenson N, Haffner C, Bruns HA. Active Immune Response Protects Stat6VT Transgenic Mice from Developing a Lymphoproliferative Disorder. (2009)Immunobiology. 215(7):579-585
Thieu VT, Nguyen ET, McCarthy BP, Bruns HA, Kapur R, Chang CH and Kaplan MH. IL-4 stimulated NF-kappaB activity is required for Stat6 DNA binding. (2007) J Leuk Biol. 82: pp. – ePub ahead of print
Bruns HA, Kaplan MH. The Role of Constitutively Active Stat6 Proteins in Leukemia and Lymphoma. (2006) Critical Reviews in Oncology/Hematology 57: 245-253.
Chang H-C, Zhang S, Thieu VT, Slee RB, Bruns HA, Laribee RN, Klemsz MJ, Kaplan MH. PU.1 expression delineates heterogeneity in primary Th2 cells. (2005) Immunity, 22: 693-703
Bruns HA, Schindler U, Kaplan MH. Expression of a Constitutively Active Stat6 in vivo Alters Lymphocyte Homeostasis with Distinct Effects in T and B Cells. (2003) Journal of Immunology, 170: 3478-3487.
Broxmeyer HE, Bruns HA, Zhang S, Cooper S, Hangoc G, McKenzie AN, Dent AL, Schindler U, Naeger LK, Hoey T, and Kaplan MH. Th1 Cells Regulate Hematopoietic Progenitor Cell Homeostasis by Production of Oncostatin M. (2002) Immunity, 16: 815-825
Lawless VA, Zhang S, Ozes ON, Bruns HA, Oldham IL, Hoey T, Grusby MJ and Kaplan MH. Stat4 Regulates Multiple Components of IFN-gamma-inducing Signaling Pathways. (2000) Journal of Immunology, 165: 6803-6808
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