The following information provides insight into the research and publications of the faculty within the Fisher Institute of Health and Well-Being. Please contact the Institute or the faculty person involved in the publication directly if you have any questions.

2018 Publications (Previous Years:  2015, 2016, 2017)

  • de Souza e Silva CG, Kaminsky LA, Arena R, Christle J, Araujo CGS, Lima RM, Ashley EM, Myers J.  A Reference Equation for Maximal Aerobic Power for Treadmill and Cycle Ergometer Exercise Testing: Analysis from the FRIEND Registry. Background Maximal oxygen uptake (VO2max) is a powerful predictor of health outcomes. Valid and portable reference values are integral to interpreting measured VO2max; however, available reference standards lack validation and are specific to exercise mode. This study was undertaken to develop and validate a single equation for normal standards for VO2max for the treadmill or cycle ergometer in men and women. Methods Healthy individuals ( N = 10,881; 67.8% men, 20-85 years) who performed a maximal cardiopulmonary exercise test on either a treadmill or a cycle ergometer were studied. Of these, 7617 and 3264 individuals were randomly selected for development and validation of the equation, respectively. A Brazilian sample (1619 individuals) constituted a second validation cohort. The prediction equation was determined using multiple regression analysis, and comparisons were made with the widely-used Wasserman and European equations. Results Age, sex, weight, height and exercise mode were significant predictors of VO2max. The regression equation was: VO2max (ml kg-1 min-1) = 45.2 - 0.35*Age - 10.9*Sex (male = 1; female = 2) - 0.15*Weight (pounds) + 0.68*Height (inches) - 0.46*Exercise Mode (treadmill = 1; bike = 2) ( R = 0.79, R2 = 0.62, standard error of the estimate = 6.6 ml kg-1 min-1). Percentage predicted VO2max for the US and Brazilian validation cohorts were 102.8% and 95.8%, respectively. The new equation performed better than traditional equations, particularly among women and individuals ≥60 years old. Conclusion A combined equation was developed for normal standards for VO2max for different exercise modes derived from a US national registry. The equation provided a lower average error between measured and predicted VO2max than traditional equations even when applied to an independent cohort. Additional studies are needed to determine its portability.Eur J Prev Cardiol.  In press, 2018.
  • Moneghetti KJ, Hock J, Kaminsky LA, Arena R, Haddad F, Wheeler M, Froelicher V, Ashley E, Myers J, Christle JW. Applying Current Normative Data to Prognosis in Heart Failure: The Fitness Registry and the Importance of Exercise National Database (FRIEND)  Percent of predicted peak VO2 (ppVO2) is considered a standard measure for establishing disease severity, however, there are known limitations to traditional normative values. This study sought to compare ppVO2 from the newly derived "Fitness Registry and the Importance of Exercise: a National Database" (FRIEND) registry equation to conventional prediction equations in a clinical cohort of patients undergoing cardiopulmonary exercise testing (CPX). Intl J Cardiol. In press, 2018.
  • Sabbini, A., Arena, R., Kaminsky, L.A., Myers, J., Phillips, SA,  Peak blood pressure responses during maximal cardiopulmonary exercise testing: Reference Standards from FRIEND (Fitness Registry and the Importance of Exercise National Database). Hypertension. The objective of this study is to expand on previous efforts in establishing normative standards of exercising blood pressure (BP) at maximal physical exertion derived from treadmill cardiopulmonary exercise testing in the United States. Four experienced laboratories in the United States with established quality control procedures contributed data from September 1, 1986, to February 1, 2015. A total of 2917 maximal (peak respiratory exchange ratio ≥1.00) treadmill cardiopulmonary exercise testing responses from apparently healthy men and women (aged 20-79 years) without cardiovascular disease were submitted to FRIEND (Fitness Registry and the Importance of Exercise: A National Database). Percentiles of maximal systolic and diastolic BP were determined for each decade. Our results show a continued increase in peak systolic BP with age in both men and women to the sixth decade, followed by a plateau between the sixth and seventh decades. However, the trajectory of peak diastolic BP with age is different between men and women. Men showed an increase in peak systolic BP until the fifth decade, which plateaued by the seventh decade. In contrast, women showed a continued increase in peak diastolic BP across each decade. Existing reference data for exercising BP have not been updated for >20 years. Normative peak exercising BP values from FRIEND can be used to provide a more current representation of maximal BP during exercise testing in the US population. 71:229-236, 2018.
  • Min J, Yan AF, Wang VHC, Wang Y. Obesity, body image, and its impact on children's eating and exercise behaviors in China: A nationwide longitudinal study. Body image seems to mediate the association between obesity and health behaviors as well as weight control attempts. We examined the distribution of children's body image by demographic characteristics and their subsequent associations with eating, exercise, and weight change. Child body image and health behaviors from the China Health National Survey 2000–2011 were assessed at baseline and in follow-up for 6- to 17-year-old children during 2000–2011 using mixed models. Prev Med. 2018 Jan;106:101-106. doi: 10.1016/j.ypmed.2017.10.024. Epub 2017 Oct 21. PMID: 29066373

  • Wang V, Min J, Xue H, Xu F, Wang H, Wang Y. What factors may contribute to sex difference in childhood obesity prevalence in China? Objective:  Previous studies in China showed large sex differences in childhood overweight and obesity (OW/OB) rates. However, limited research has examined the cause of these sex differences. The present study aimed to examine individual and parental/familial factors associated with sex differences in childhood OW/OB rates in China. Public Health Nutr. 2018 Feb 26:1-9. doi: 10.1017/S1368980018000290. [Epub ahead of print].
  • Min J, Kim G, Lim H, Carvajal N, Lloyd C, Wang Y. A kindergarten-based child health promotion program- the Adapted National Aeronautics and Space Administration (NASA) Mission-X to improve physical fitness in South Korea. Global Health Promotion. 2018. Accepted.