Associate Professor of Physiology
Clinical Medical Research Training at the Cleveland Clinic (1999-2000)
Postdoctoral Fellow at Northwestern University (1997-1999)
Wayne State University School of Medicine, Ph.D. (1997)
Wayne State University,BS (1992)
Henry Ford CC, AA & AS (1989)
My general interests are in autoimmune, neurological and cardiovascular disease as well as the basic mechanisms that differ between normal and disease state.
Specific Goals: Examining 1) determine the role of autoimmune antibodies in the development of disease especially streptococcal related diseases as well as the sites of antibody interactions (Figure 1), 2) examine the distribution of SNARE proteins involved in exocytosis including those involved in the process of antibody release (Figure 2), 3) determining the basic mechanisms behind disease development in general, 4) search for ways to prevent development or spread of disease.
Figure 1. Autoimmune antibodies are visualized in the midrostral caudate/putamen region of the brain. A cloud of fluorescence indicates the presence of antibody observed within the brain in rats injected with the streptococcal generated monoclonal antibody 10F5 24 hours after injection (A) and in the myosin (type II) antibody treated rats at 48 hours (B). This phenomena was not observed in IgG2b injected negative controls (C).
Figure 2. Exocytosis is drive by basic SNARE proteins as well as other proteins that are found in the vesicle membrane and plasma membrane. Different types of SNARE proteins are compartmentalized to specific locations within the cell and different cell types may possess different SNAREs. A non-neuronal vesicle is shown docked to the plasma membrane prior to release of its contents in the figure to the left.
In our research, we:
- Examine autoimmune antibody interactions with cells and tissues (heart, brain, liver and kidney).
- Determine if development of disease can be linked to the presence of antibody.
- Examine cells for the presence and distribution of SNARE proteins involved in exocytosis.
- Examine current literature and research to dissect the basic mechanisms behind disease state.
- Create models to prevent the spread of disease state.
Robyn Gebhard, Courtney Huff, Mathew Osborne, Lisa Riegle, M. Kelly-Worden. 2015. Streptococcal Antibody Probe Crosses the Blood Brain Barrier and Interacts within the Basal Ganglia. OJPathology. 5:42-49. Impact Factor=0.22.
Morenci Manning, M. Kelly-Worden. 2015. Potential Regulators of Sporadic ALS Development and Alternative Therapeutic Options. Neuroscience & Medicine. 6(1):5-12. Impact Factor=0.47.
M. Kelly-Worden, Emily Thomas. 2014. Mitochondrial Dysfunction in Duchenne Muscular Dystrophy. Open Journal of Endocrine and Metabolic Diseases (OJEMD). 4(8):211-218. Impact Factor=0.63.
M. Kelly-Worden, Leslie Hammer, Robyn Gebhard, Lauran Schrader, Marley Griffin, Dalahnna Cooper. 2014. ANA Positive Serum from SLE Patients Promotes Cardiovascular and CNS Manifestations in the Lewis Rat. J Pharm Bioall Sci. 6(3):198-204.
Fatimah Albrekkan and M. Kelly-Worden. 2013. Mitochondrial Dysfunction and Alzheimer’s Disease. OJEMD. 3(2A):14-19. Impact Factor=0.63.
Jarial, Mohinder and M. Kelly-Worden. 2011. Additional ultrastructural observations of the first segments of Malpighian tubules in Cenocorixa bifida (Hemiptera: Corixidae) in relation to reabsorption of solutes. Ann. Entomol. Soc. Am. 104(4):768-777. Impact Factor=1.317
Debora A., M. L. Kelly and D. J. Woodbury. 2006. SNARE complex regulation by phosphorylation. Cell Biochemistry and Biophysics. 45(1):111-124. Impact Factor = 4.312
Kelly, M. L., R. Abu-Hamdah, A. Jeremic, S. –J. Cho, A. E. Ilie and B. P. Jena. 2005. Patch clamped single pancreatic zymogen granules; direct measurements of ion channel activities at the granule membrane. Pancreatology. 5(4-5):443-449. Impact Factor = 2.2.
Kelly, M. L., W. –J. Cho, A. Jeremic, R. Abu-Hamdah and B. P. Jena. 2004. Vesicle swelling regulates content expulsion during secretion. Cell Biology International. 28(10): 709-716. Impact Factor = 1.747
Abu-Hamdah, R., W. -J. Cho, S. -J. Cho, A. Jeremic, M. Kelly, A. E. Ilie and B. P. Jena. 2004. Regulation of the water channel aquaporin-1: isolation and reconstitution of the regulatory complex. Cell Biology International. 28(1):19-31. Impact Factor = 1.747
Jeremic A., M. Kelly, J. A. Cho, S. –J. Cho, H. Horber and B. P. Jena. 2004. Calcium drives fusion of SNARE-apposed bilayers. Cell Biology International. 28(1):7-17. Impact Factor = 1.747.
Kelly, M. L., J. A. Cook, P. Brown-Augsburger, B. A. Heinz, M. C. Smith and L. H. Pinto. 2003. Demonstrating the Intrinsic Ion Channel Activity of Virally-Encoded Proteins. FEBS Letters. 552(1):61-67. Impact Factor = 3.601
Jeremic, A., M. Kelly, S. –J. Cho, M. Stromer, and B. P. Jena. 2003. Reconstituted fusion pore. Biophysical Journal 85:2035-2043. Impact Factor = 4.39
Cho, S. –J., M. Kelly, K. T. Rognlien, J. A. Cho, H. Horber and B. P. Jena. 2002. SNAREs in opposing bilayers interact in a circular array to form conducting pores. Biophysical Journal. 83:2522-2527. Impact Factor = 4.39
Tobler, K., M. L. Kelly, L. H. Pinto, and R. A. Lamb. 1999. Effect of cytoplasmic tail truncations on the activity of the M(2) ion channel of influenza A virus. Journal of Virology. 73(12):9695-701. Impact Factor = 5.189
Kelly, M. L. and D. J. Woodbury. 1996. Ion channels from cholinergic synaptic vesicle fragments reconstituted into lipid bilayers. Biophysical Journal. 70:2593-2599. Impact Factor = 4.39
Woodbury, D. J. and M. Kelly. 1994. Release of ATP from cholinergic synaptic vesicles during freeze-thaw cycling. Cryobiology. 31:279-289. Impact Factor = 1.830
Tourette Syndrome Association
Gold Key International Honour Society
Lupus Foundation of America
Honorary member, Eta Sigma Gamma
Indiana Academy of Science
American Society for Cell Biology
Medical Research Advisor, Dysautonomia Information Network
Society for Neuroscience