The Department of Chemistry hosts a seminar series during the academic year featuring presentations by individuals (students, faculty, and invited guests) discussing their research within the field of chemistry. These presentations are free and open to the public.
Click here to view previous semester's seminar schedules.
Thursday, October 6, 2016 - 3:30PM, CL 278
Catalytic Asymmetric Chloro Functionalization of Olefins: Methodology and Mechanistic Considerations
Prof. Babak Borhan
Michigan State University
Until recently, catalytic asymmetric halofunctionalization reactions have been difficult to tame. In the past five years, however, a number of new methodologies have demonstrated the ability to control olefin facial selectivity in a variety of transformations, including halocyclizations, and inter and intramolecular haloetherification reactions. The key feature of these transformations resides with suppression of non-catalyzed background reactions that erode enantioselectivity. Moreover, competing processes such as olefin to olefin transfer of the halenium and also lack of stereochemical control in nucleophilic addition to the halo-added olefin intermediates are challenges that need to be addressed in order to deliver a highly stereoselective transformation. Though it has seen great progress, the field of stereoselective alkene halogenation has mainly advanced via a trial-and-error approach. Further progress in this area requires rational and mechanistically based approaches; the detailed nature of attack on alkenes by halenium ion donors must be understood, along with the structural and electronic character of any resulting intermediates. Despite their appearance in every sophomore organic class, the traditionally invoked cyclic three-membered halonium ion intermediates do not adequately explain a number of electrophilic halenium-initiated alkene additions, including many of our own halocyclizations. Our recent studies towards a better understanding of factors that control stereoselectivity will be presented. We have used a new parameter, halenium affinity, as a thermodynamic parameter to gauge the reactivity of various functional groups with different halenium sources. We will also discuss a number of mechanistic studies, including kinetic measurements and KIEs to unravel factors at play that result in the observed stereochemical events.
Thursday, September 1, 2016
Professor Prashant V. Kamat
Radiation Laboratory; Department of Chemistry & Biochemistry; Department of Chemical Biomolecular Engineering, University of Notre Dame
"Lead Halide Hybrid Perovskites as Efficient Light Energy Harvesters"
Thursday, September 8, 2016
Dr. Jennifer S. Holt
Assistant Professor of Chemistry, Valparaiso University
"Behavior of Brooker’s Merocyanine in Host-Guest Materials"
Thursday, October 6, 2016
"Catalytic Asymmetric Chloro Functionalization of Olefins: Methodology and Mechanistic Considerations"
Thursday, October 20, 2016
Prof. Rainer Glaser
University of Missouri
Thursday, October 27, 2016
Dr. Jeff Gilbert
Friday, November 11, 2016
Mr. Daniel Miller & Dr. Sundeep Rayat
Chemistry, Ball State University
Thursday, November 17, 2016
Dr. Ryan Jeske
Assistant Professor of Chemistry, Ball State University
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