Associate Professor of Chemistry
Postdoctoral Researcher Ohio State University (2003)
Australian National University Ph.D. (1999)
University of Sydney B.Sc. (1991)
Our group is interested in the chemistry of reactive intermediates. These are compounds that are formed and destroyed in the course of a chemical reaction, and are responsible for chemical reactivity. Depending on the intermediate, these species have lifetimes ranging from thousandths to billionths of a second. We, in conjunction with our collaborators, use a number of techniques; from standard analytical methods (UV, NMR, GC and HPLC) to highly specialized techniques such as laser flash photolysis (LFP), matrix isolated infra-red and EPR spectrometry, as well as high-level computational methods, to understand the structure and reactivity of these short-lived species.
Current Research Projects
The Chemistry of Heteroaryl Nitrenes
We have found that the nitrenopyridine
-oxides exhibit chemistry which is unlike that of simple aryl nitrenes, and the nature of the chemistry observed depends on the position of the nitreno- group, relative to the
-oxide moiety. We have observed the photochemistry of these species at both 298K, and at cryogenic temperatures:
Our current work involves investigations of the effect of s
ubstitution, and the
photochemistry of nitreno-quinoline and isoquinoline systems, as well as di-
- Poole, J.S. “A Computational Study of the Chemistry of Substituted 3-Nitrenopyridine 1-Oxides”, J. Mol. Struct.:THEOCHEM, 2009, 894, 93.
- Crabtree, K.N.; Hostetler, K.J.; Munsch, T.E.; Neuhaus, P.; Lahti, P.L.; Sander, W.; Poole, J.S. “Comparative Study of the Photochemistry of the Azidopyridine 1 Oxides”, J. Org. Chem., 2008, 73, 3441.
- Hostetler , K.J.; Crabtree, K.N.; Poole, J.S. "The Photochemistry of 4-Azidopyridine-1-Oxide", J. Org. Chem., 2006, 71, 9023-9029.
The Chemistry of Hydroxyl Radical
We are performing combined laser flash photolysis and product analysis studies to understand the reactivity and selectivity of hydroxyl radical reaction with aromatic substrates in non-aqueous, and partially aqueous solvent systems. Early LFP studies indicate that the reactions are largely dominated by hydroxyl addition reactions, and the measured rates of reaction at 298K show correlations indicative of charge-transfer contributions in the transition state. Unfortunately, LFP studies are unable to elucidate the chemo- and regioselectivity of such reactions. We have developed a product analysis method that allows us to probe these issues, and investigate their temperature
- DeMatteo, M; Poole, J S; Shi, X; Sachdeva, R; Hatcher, P G; Hadad, C M; Platz, M S; "On the Electrophilicity of Hydroxyl Radical: A Laser Flash Photolysis and Computational Study." J. Am. Chem. Soc. 2005, 127, 7094.
- Poole, J S; Shi, X; Hadad, C M; Platz, M S; "Reaction of Hydroxyl Radical with Aromatic Hydrocarbons in Non-Aqueous Solutions — a Laser Flash Photolysis Study in Acetonitrile." J. Phys. Chem. A. 2005, 109, 2547.