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CL 229d Phone: 765-285-3510
Department of Biology
Ball State University
Cooper Life Science Building, CL 121
Muncie, IN 47306
Bowling Green State University, Ph.D. ,1994
The Ohio State University, M.S. ,1987
Bowling Green State University, B.S. ,1983
TAL-1 transcription factor
My general interests are in molecular and cancer biology.
Specific Goal: Understanding how ectopic expression of the transcription factor, TAL-1 (see Fig. 1), contributes to leukemogenesis. Through ill-defined mechanisms, TAL-1 seems to play a significant role in the progression of T-cell acute lymphoblastic leukemia. It is thought that important cellular processes such as cell cycle control, cell signaling and apoptosis (see Fig. 2) are influenced by this mis-expressed protein. Through investigating
Image from Cell Signaling Technology website
potential targets of TAL-1, it is hoped that a better picture of how TAL-1 influences apoptotic resistance and cell survival will be realized. In the end, this type of research will hopefully guide the future development of better, more targeted therapies to treat T-ALL at the molecular level.
In our research, we:
Bombuwala, K., Kinstle, t., Popik, V., Uppal, S., Olesen, J.B., Vina, J. and Heckman, C.A. (2006). Colchitaxel, A Coupled Compound Made from Microtubule Inhibitors Colchcine and Paclitaxel. Beilstein Journal of Organic Chemistry 2:13-22.
Olesen, J.B. and Gough, E. (2006). Optimization of Transfection Conditions for the Human HL-60 Promyelocytic Leukemic T-Cell Line Using FuGene HD Transfection Reagent. Biochemica, 3:24-25.
Lucas, B. and Olesen, J.B. Ectopic expression of TAL-1 increases resistance to TNFα-induced apoptosis in Jurkat cells via changes in the NF-κB signaling pathway. In preparation.
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