Biology5

VJ Rubenstein

Assistant Professor

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CL 171a  Phone: 765-285-8805  

Department of Biology
Ball State University
Cooper Life Science Building, CL 121
Muncie, IN 47306

Education and Training:

Yale University, Postdoctoral Fellowship (2008 - 2012)
University of Pittsburgh School of Medicine, Ph.D. (2003 - 2008)
Grove City College, B.S. (1998 - 2002)

Research Interests:

General:
• Cell and molecular biology
• Protein quality control

Specific:
• Protein degradation in Saccharomyces cerevisiae
• Endoplasmic Reticulum-Associated Degradation (ERAD) of translocon-associated proteins
• Novel roles for the ubiquitin ligases of the endoplasmic reticulum membrane

Publications:
Rubenstein EM, Kreft SG, Greenblatt W, Swanson RJ, Hochstrasser M. Aberrant substrate engagement of the Sec61 translocon triggers degradation by the Hrd1 ubiquitin ligase. J Cell Bio 197, No. 6 (761-773), 2012.

Rubenstein EM, Hochstrasser M. Redundancy and variation in the ubiquitin-mediated proteolytic targeting of a transcription factor. Cell Cycle 9, No. 21 (4282-4285), 2010.

Rubenstein EM, Schmidt MC. The glucose signal and metabolic p[H+]lux. EMBO Journal 29, No. 15 (2473-2474), 2010.

Xie Y, Rubenstein EM, Matt T, Hochstrasser M. SUMO-independent in vivo activity of a SUMO-targeted ubiquitin ligase toward a short-lived transcription factor. Genes and Development 24, No. 9 (893-903), 2010.

Rubenstein EM, McCartney RR, Zhang C, Shokat KM, Shirra MK, Arndt KM, Schmidt MC. Access denied: Snf1 activation loop phosphorylation is controlled by availability of the phosphorylated threonine 210 to the PP1 phosphatase. Journal of Biological Chemistry 283, No. 1 (222-230), 2008.

Rubenstein EM, Schmidt MC. Mechanisms regulating the protein kinases of Saccharomyces cerevisiae. Eukaryotic Cell 6, No. 4 (571-583), 2007.

Elbing K, Rubenstein EM, McCartney RR, Schmidt MC. Subunits of the Snf1 kinase heterotrimer show interdependence for association and activity. Journal of Biological Chemistry 281, No. 36 (26170-26180), 2006.

Rubenstein EM, McCartney RR, Schmidt MC. Regulatory Domains of the Snf1-Activating Kinases Determine Pathway Specificity. Eukaryotic Cell 5, No.4 (620-627), 2006.

McCartney RR, Rubenstein EM, Schmidt MC. Snf1 kinase complexes with different beta subunits display stress-dependent preferences for the three Snf1-activating kinases. Current Genetics 47, No. 6 (335-344), 2005. 
 

Course Schedule