VJ Rubenstein

Assistant Professor

CL 171a  Phone: 765-285-8805  

Department of Biology
Ball State University
Cooper Life Science Building, CL 121
Muncie, IN 47306

Education and Training:

Yale University, Postdoctoral Fellowship (2008 - 2012)
University of Pittsburgh School of Medicine, Ph.D. (2003 - 2008)
Grove City College, B.S. (1998 - 2002)

Research Interests:

• Cell and molecular biology
• Protein quality control

• Protein degradation in Saccharomyces cerevisiae
• Endoplasmic Reticulum-Associated Degradation (ERAD) of translocon-associated proteins
• Novel roles for the ubiquitin ligases of the endoplasmic reticulum membrane

Rubenstein EM, Kreft SG, Greenblatt W, Swanson RJ, Hochstrasser M. Aberrant substrate engagement of the Sec61 translocon triggers degradation by the Hrd1 ubiquitin ligase. J Cell Bio 197, No. 6 (761-773), 2012.

Rubenstein EM, Hochstrasser M. Redundancy and variation in the ubiquitin-mediated proteolytic targeting of a transcription factor. Cell Cycle 9, No. 21 (4282-4285), 2010.

Rubenstein EM, Schmidt MC. The glucose signal and metabolic p[H+]lux. EMBO Journal 29, No. 15 (2473-2474), 2010.

Xie Y, Rubenstein EM, Matt T, Hochstrasser M. SUMO-independent in vivo activity of a SUMO-targeted ubiquitin ligase toward a short-lived transcription factor. Genes and Development 24, No. 9 (893-903), 2010.

Rubenstein EM, McCartney RR, Zhang C, Shokat KM, Shirra MK, Arndt KM, Schmidt MC. Access denied: Snf1 activation loop phosphorylation is controlled by availability of the phosphorylated threonine 210 to the PP1 phosphatase. Journal of Biological Chemistry 283, No. 1 (222-230), 2008.

Rubenstein EM, Schmidt MC. Mechanisms regulating the protein kinases of Saccharomyces cerevisiae. Eukaryotic Cell 6, No. 4 (571-583), 2007.

Elbing K, Rubenstein EM, McCartney RR, Schmidt MC. Subunits of the Snf1 kinase heterotrimer show interdependence for association and activity. Journal of Biological Chemistry 281, No. 36 (26170-26180), 2006.

Rubenstein EM, McCartney RR, Schmidt MC. Regulatory Domains of the Snf1-Activating Kinases Determine Pathway Specificity. Eukaryotic Cell 5, No.4 (620-627), 2006.

McCartney RR, Rubenstein EM, Schmidt MC. Snf1 kinase complexes with different beta subunits display stress-dependent preferences for the three Snf1-activating kinases. Current Genetics 47, No. 6 (335-344), 2005.